بررسی رابطه پلی‌مورفیسم تک‌نوکلئوتیدی T/C در ژن CYP1A1 با شروع بیماری و استعمال سیگار در بیماران مبتلا به سرطان ریه

Abstract Background: Several single nucleotide polymorphisms have been found in CYP1A1 gene and it was reported that C allele in T/C gene polymorphism is associated with lung cancer. Current study investigates interaction between cigarette factor and C/T polymorphism in the m1 locus. Methods: Present study is a case-control and retrospective study. T/C polymorphism in 112 patients with lung cancer and 120 healthy controls was genotyped using RFLP-PCR technique. Association of the polymorphism and initiation of cancer including cigarette risk factor was analyzed statistically. Results:, Association was seen between patient and control groups in the distribution of gene polymorphism (P<0.0001). No significant difference was seen in distribution of gene polymorphism between the two patient groups (smokers and non-smokers) (P=0.098). Conclusion: Results of present study show individuals with C allele are susceptible to lung cancer independent of cigarette smoking factor in Isfahan population. However determining the role of C allele as a biological risk factor needs more investigation. Keywords: Lung cancer, CYP1A1, Single nucleotide polymorphism, Cigarette.